Common dosage forms of NMN dietary supplements are enteric-coated sustained-release tablets and capsules, as well as sublingual powders and buccal tablets. Many people think that taking NMN through the sublingual mucosa can quickly enter the blood circulation, be more efficient, and prevent NMN components from being inhibited and absorbed by the liver, but this is not the case.

Problems with sublingual administration

Sublingual administration means that the drug is absorbed through the rich capillaries of the sublingual mucosa, so that the drug can directly enter the blood circulation. However, there will be the following problems:

1. Security issues

You must know that the small intestine is the main organ for the human body to digest food and absorb nutrients, but the sublingual is obviously not. Taking it under the tongue for a long time will make the sublingual capillaries thick and accumulate into bundles, which is not beneficial in the long run.

It should be noted that many chemically synthesized NMNs on the market will synthesize a certain composition of α-NMN, and of course there are some chemical residues. α-NMN has no biological activity, has high safety hazards, and has unknown risks to the next generation's inheritance. And such NMN products bypass the links of liver detoxification and kidney metabolism, and directly enter the blood. It is conceivable that it will bring great risks to the DNA damage of nerve cells.

2. Absorption problem

First of all, NMN sublingual lozenges are decomposed by saliva in the mouth, and are directly decomposed by gastric acid after being swallowed into the stomach. The content of NMN reaching the small intestine is continuously reduced, and the gastric mucosa may be irritated during this process.

Secondly, the area under the tongue is relatively small, and the tongue is not an absorption organ, resulting in a low absorption rate.

Why is the absorption rate of enteric-coated capsules higher?

Therefore, whether it is an NMN dietary supplement or a drug, it is made into an enteric-coated type for the following reasons:

1. Better absorption effect

The stomach plays the role of a "temporary warehouse", and the gastric acid in the gastric juice is a strong acid. When food enters the stomach, it will be decomposed by many digestive enzymes and lysozyme. When the food enters the small intestine, under the action of bile and pancreatic juice, it is finally completely decomposed into small molecule nutrients that can be absorbed by the human body. Absorption of these nutrients is also done in the small intestine.

Therefore, enteric-coated NMN works directly in the intestine, and the digestion and absorption effect will be better.

2. Maximum activity retention

NMN is a naturally occurring biologically active nucleotide. And acting on the metabolism of human cells is also the role of this biological activity.

The capsule NMN has a layer of enteric coating, which will not start to decompose until it enters the small intestine, so as to prevent NMN from being decomposed and destroyed by gastric acid, better retain the NMN nutrients, and allow the body to absorb it to a greater extent.

This is why the utilization rate and absorption rate of capsule NMN will be higher. Compared with sublingual tablets, enteric-coated capsule NMN became a safer and more effective preparation.